SrIA (P03752) Protein Card

General Information

Name	SrIA
Alternative name(s)	Sr1A
Organism	Conus spurius
Organism region	Western Atlantic and Caribbean
Organism diet	vermivorous
Protein Type	Wild type
Protein precursor	SrIA/SrIB precursor (3751)
Notes	SrIB has the same sequence as SrIA except for position 12, which is a glutamate in SrIB and a gamma-carboxylic glutamic acid in SrIA. SrIA and SrIB are encoded by the same gene, and their distinct sequence arises from the partial post-translational modification of position 12.

Classification

Conopeptide class	conotoxin
Gene superfamily	A superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

RTCCSROTCRM(Gla)YP(Gla)LCG(nh2)
Modified residues	position symbol name 7 O 4-Hydroxyproline 12 Gla Gamma carboxylic glutamic acid 15 Gla Gamma carboxylic glutamic acid 19 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	2204.46
Monoisotopic Mass	2202.84
Isoelectric Point	10.50
Extinction Coefficient [280nm]	1490.00

Synthetic variants

Sr1.1

RTCCSROTCRMEYPELCG(nh2)

References

López-Vera,E., Aguilar,M.B., Schiavon,E., Marinzi,C., Ortiz,E., Restano Cassulini,R., Batista,C.V., Possani,L.D., Heimer de la Cotera,E.P., Peri,F., Becerril,B. and Wanke,E. (2007) Novel alpha-conotoxins from Conus spurius and the alpha-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS J. 274:3972-3985

Internal links

Protein Precursor	SrIA/SrIB precursor (3751)
Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Sunday 2 April 2023