Conkunitzin-S1 (P01376) Protein Card

General Information
Name Conkunitzin-S1
Organism Conus striatus (Striated cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework XIV [connectivity I-III, II-IV]
Pharmacological family

Sequence
KDRPSLCDLPADSGSGTKAEKRIYYNSARKQCLRFDYTGQG
GNENNFRRTYDCQRTCLYT
Sequence evidence Unknown
Average Mass 6929.63
Monoisotopic Mass 6925.23
Isoelectric Point 9.93
Extinction Coefficient [280nm] 7450.00

References
Dy,C.Y., Buczek,P., Imperial,J.S., Bulaj,G. and Horvath,M.P. (2006) Structure of conkunitzin-S1, a neurotoxin and Kunitz-fold disulfide variant from cone snail. Acta Crystallogr. D Biol. Crystallogr. 62:980-990
Bayrhuber,M., Vijayan,V., Ferber,M., Graf,R., Korukottu,J., Imperial,J., Garrett,J.E., Olivera,B.M., Terlau,H., Zweckstetter,M. and Becker,S. (2005) Conkunitzin-S1 is the first member of a new Kunitz-type neurotoxin family. Structural and functional characterization. J. Biol. Chem. 280:23766-23770

Internal links
Nucleic acids
Structure A 2.4 CRYSTAL STRUCTURE OF CONKUNITZIN-S1, A NOVEL KUNITZ- FOLD CONE SNAIL NEUROTOXIN.

External links
Ncbi 73535576

Tools