ConoServer Statistics
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Logo representation of the signal sequence alignment
Sequence consensus at 60% identity conservation and aternative amino acids found at each position
M G M R M X X M F T V F L L V V L A T T V V S X T S X X
G I R M V V I M C M F G A F T I A L G P F P L G G
S V L G P S L I T W S S D T T I N D R
S I G V A R I A L S S A
A S S Q I I F P
L N N L T
D Y
S
Amino acid frequency per position (184 signal sequences)
| Position | Consensus | Amino acid occurence | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | M | (90) | ||||||||||||||
| 2 | G | G | (91) | ||||||||||||||
| 3 | M | M | (93) | ||||||||||||||
| 4 | R | R | (92) | G | (0) | ||||||||||||
| 5 | M | M | (92) | I | (0) | ||||||||||||
| 6 | X | R | (1) | ||||||||||||||
| 7 | X | M | (1) | ||||||||||||||
| 8 | M | M | (182) | V | (0) | ||||||||||||
| 9 | F | F | (177) | V | (2) | S | (2) | ||||||||||
| 10 | T | T | (169) | I | (9) | V | (1) | S | (0) | A | (0) | ||||||
| 11 | V | V | (163) | M | (16) | L | (1) | I | (0) | ||||||||
| 12 | F | F | (181) | C | (0) | G | (0) | ||||||||||
| 13 | L | L | (174) | M | (6) | P | (1) | ||||||||||
| 14 | L | L | (180) | F | (1) | S | (0) | ||||||||||
| 15 | V | V | (181) | G | (0) | L | (0) | ||||||||||
| 16 | V | V | (173) | A | (3) | I | (1) | G | (1) | S | (0) | L | (0) | ||||
| 17 | L | L | (178) | F | (1) | T | (0) | ||||||||||
| 18 | A | A | (153) | T | (23) | W | (1) | V | (1) | S | (0) | ||||||
| 19 | T | T | (168) | I | (4) | S | (3) | A | (1) | Q | (1) | N | (0) | ||||
| 20 | T | T | (169) | A | (4) | S | (2) | R | (1) | I | (0) | N | (0) | ||||
| 21 | V | V | (169) | L | (8) | D | (0) | I | (0) | ||||||||
| 22 | V | V | (158) | G | (4) | T | (2) | A | (2) | I | (2) | L | (1) | D | (1) | S | (0) |
| 23 | S | S | (148) | P | (4) | T | (1) | L | (1) | F | (0) | ||||||
| 24 | X | F | (25) | I | (7) | S | (5) | P | (0) | T | (0) | Y | (0) | ||||
| 25 | T | T | (22) | P | (7) | N | (3) | S | (0) | ||||||||
| 26 | S | S | (28) | L | (3) | ||||||||||||
| 27 | X | G | (8) | D | (3) | A | (0) | ||||||||||
| 28 | X | G | (1) | R | (1) |
Signal sequence alignment
A4.1 precursor (3917) -------MFTVFLLVVLATTVVS----- A4.2 precursor (3920) -------MFTVFLLVVLATTVVS----- Ac1.1a precursor (570) MGMRM--MFTLFLLVVLTTTVVS----- Ac1.1b precursor (2989) -------MFTVFLLVVLTTTVVS----- Ac1.1b precursor (571) MGMRM--MFTLFLLVVLTTTVVS----- Ac1.1b precursor (545) MGMRM--MFTVFLLVVLTTTVVSYPS-- Ac1.2 precursor (2987) -------MFTVFLLVVLTTTVVS----- Ac4.1 precursor (3914) -------MFTVFLLVVLATTLVSIP--- Ac4.2 precursor (3915) -------MFTVFLLVVLATTLVS----- Ai1.1 precursor (2943) -------MFTVFLLVVLATTVVS----- Ai1.2 precursor (2945) -------MFTVFLLVVLATTVVSS---- AuIA precursor (2878) -------MFTVFLLVVLATTVVS----- AuIB precursor (2879) -------MFTVFLLVVLATTVVS----- Be1.1 precursor (2906) -------MFSVFLLVVLATTVVSSTSG- Be1.2 precursor (2908) -------MFTVFLLVVLATTVVSFTSG- Be1.3 precursor (2910) -------MFTVFLLVVLATTVVSFTSG- Be1.4 precursor (2912) -------MFTVFLLVVLATTVVS----- Be1.5 precursor (2914) -------MFTVFLLVVLATTVVSFTSG- Be1.6 precursor (2991) -------MFTVFLLVVLATTVVS----- Bn1.1 precursor (19) MGMRM--MFTMFLLVVLATTVVS----- Bn1.3 precursor (20) MGMRM--MFTVFLLVVLATA-------- Bt1.61 precursor (4563) MGMRM--MFTVFLLVVLATTVV------ Bt1.91 precursor (4564) MGMRM--MFTVFLLVVLATTVV------ Bu1.1 precursor (2931) MGMRM--MFTVFLLVV----LA------ Bu1.2 precursor (2933) -------MFTVFLLVVLATTVVS----- Bu1.3 precursor (4576) MGMRMRMMFTVFLLVVLANTVVS----- Bu1.3 precursor (2935) -------MFTVFLLVVLATTVVS----- Bu19 precursor (4574) MGMRM--VFTVFLLVVLATTVVS----- Bu23 precursor (4581) MGMRM--MVTVFLLGVLATTVVS----- Bu24 precursor (4583) MGMRM--MVTVFLLVVLATTVVS----- Bu25 precursor (4585) MGMRM--MVTVFPLVVLATTVVS----- BuIA precursor (409) -------MFTVFLLVVLTTTVVS----- C4.1 precursor (3923) -------MFTVFLLVGLATTLVSIPSDG C4.1b precursor (3925) -------MFTVFLLVGLATTLVSIPSDG C4.2 precursor (3924) -------MFTVFLLVVLATTVVS----- C4.3 precursor (3926) -------MFTVFLLVVLTITVVS----- Ca1.1 precursor (11) MGMRM--MFTVFLLVVLATTVVS----- Ca1.2 precursor (13) MGMRM--MFTVFLLVVLATTVVS----- Ci1.1 precursor (2922) -------MFTVFLLVVLATTVVS----- Ci1.2 precursor (2924) -------MFTVFLLVVLATTVVS----- Ci1.3 precursor (2995) -------MFTVFLLVVLAATVVS----- Cn1.2 precursor (2939) -------MFTVFLLVVLATTVVS----- Cn4.1 precursor (3937) -------MFTVFLLVVLATTVVS----- Cn4.2 precursor (3938) -------MFTVFLLVVLATTVVS----- Cn4.3 precursor (3939) -------MFTVFLLVVLATTVVS----- Cn4.4 precursor (3940) -------MFTVFLLVVLATTVVS----- CnIA/B/K precursor (5532) MGMRM--MFTVFLLVVLTTTVVS----- CnIA/B/L precursor (5244) MGMRM--MFTVFLLVVLTTTVVS----- CnIC/F/H precursor (5542) MGMRM--MFTVFLLVVLTTTVVS----- CnIC/F/H precursor (5533) MGMRM--MFTVFLLVVLTTTVVS----- CnID precursor (5241) MGMRM--MFTVFLLVVLTTTVVS----- CnIH precursor (3711) -------MFTVGLLVVLTTTVVS----- CnIH precursor (2902) -------MFTVFLLVVLTTTVVS----- CnIJ precursor (3933) -------MFTVFLLVVLTTTVVS----- Cr4.1 precursor (3931) -------MFTVFLLVVLATTVVS----- Di1.1 precursor (2937) -------MFTVFLLVVFASSVTL----- E1.1 precursor (3002) -------MFTVFLLVVLATTVGS----- E1.3 precursor (3911) -------MFIVFLLVVLATTVGSFTL-- E1.3 precursor (3910) -------MFIVFLLVVLATTVGSFTL-- EI precursor (3000) -------MFTVFLLVVLATTVGS----- EpI precursor (2925) -------MFTVFLLVVLATTVVS----- Eu1.3 precursor (4506) MGMRM--MFTVFLLVVLATAVLP----- Eu1.6 precursor (4548) MGMRM--MFTVFLLVVLATTVV------ G1.5 precursor (5705) MGMRM--MFTVFLLVALATTVVS----- G1.6 precursor (5707) MGMRI--MFTVFLLVALATIVVS----- G1.7 precursor (5709) MGMRM--MFTVFLFLVLATTDVS----- G1.8 precursor (5715) MGMRM--MFTVFLLVVLATTVVS----- G1.9 precursor (5717) -GMRM--MFTVFLLVVLATTVVS----- G4.1 precursor (5723) MGMRM--MFTVFLLVA-WQRLVSS---- G4.1 precursor (5719) MGMRM--MFTVFLLVVLATTVVS----- G4.2 precursor (5721) MGMRM--MFTVFLLVSTWQRLS------ GI precursor (5714) MGMRM--MFTVFLLVVLATTVVS----- GI precursor (2975) -------MFTVFLLVVLATTVVS----- GIB precursor (5713) --MRM--MFTVFLLVVLATTVVS----- GIB precursor (2983) -------MFTVFLLVVLATTVVS----- GID precursor (5711) MGMRM--MFTVFLLVVLAATIVS----- GII precursor (4221) -------MFTVFLLVVLATTVVS----- GII precursor (5712) MGMRM--MFTVFLLVVLATTVVS----- Im1.8 precursor (4593) MGMRM--MFTVFLLVVLATAVLP----- Im1.95 precursor (4066) MGMRM--MFTVFLLVVLATTVVS----- ImIIA precursor (78) MGMRM--MFTVFLLVVLATA-------- LeD2 precursor (544) MGMRM--MFIMFMLVVLATTV------- Lp1.1 precursor (119) MGMRM--MFIMFMLVVLATTVVTFTS-- Lp1.1 precursor (543) MGMRM--MFIMFMLVVLATTV------- Lp1.2 precursor (120) MGMRM--MFTVFLLVVLATTVVS----- Lp1.3 precursor (121) MGMRM--MFIMFMLVVLATTVVS----- Lp1.4 precursor (546) MGMRM--MSIMFMLVVLATTVVSFTS-- Lp1.4 precursor (122) MGMRM--MFIMFMLVVLATTVVSFTS-- Lp1.5 precursor (126) MGMRM--MFTVFLLVILASTV------- Lp1.6a precursor (547) MGMRM--MFIIFLFVVLATTVVSFTSG- Lp1.7 precursor (553) MGMRM--MFTMFLLVVLTTTVVSFNS-- Lp1.8 precursor (552) MGMRM--MFTMFLLVVLTTTVVSFNS-- Lt1.46 precursor (4065) MGMRM--MFTVFLLVVLATTVV------ Lt1C precursor (1152) MGMRM--MFTMFLLVVLTTTVVSF---- LtIA precursor (1151) MGMRM--MFIMFMLVVLATTVVTFTS-- M1.1 precursor (2999) -------MFTVFLLVVLTTTVVS----- M4.2 precursor (3943) -------MFTVFLLVVLATTVVS----- M4.3 precursor (3944) -------MFTVFLLVVLATSVVS----- MII precursor (8) MGMRM--MFTVFLLVVLATTVVS----- MIVA precursor (18) MGMRM--MFTVFLLVVLATTVVS----- Mi1.1 precursor (2492) MGMRM--MFTVFLLVVLATTVVS----- Mn1.1 precursor (2985) -------MFTVFLLVVLTTTVVS----- Mn1.2 precursor (2993) -------MFTVFLLVVLTTTVVS----- Mn4.1 precursor (3949) -------MFTVFLLVVLATTLVSI---- Mn4.2 precursor (3950) -------MFTVFPLVVLATTLVSIPSDR Mr1.1 precursor (123) MGMRM--MFTVFLLVVLATTVVS----- Mr1.1 precursor (5365) MGMRM--MSTVFLLVVLATTVVS----- Mr1.2 precursor (127) MGMRM--MFTVFLLVVLATTVVSFTS-- Mr1.3 precursor (541) MGMRM--MFTMCLLVVLATTVISFTS-- Mr1.7 precursor (4532) MGMRM--MFTMFLLVVLATTVV------ Mr1.8 precursor (4571) MGMRM--MFTVFLLVVLATTVV------ O1.1 precursor (2947) -------MFTVFLLVVLATTVVSP---- O1.2 precursor (2949) -------MFTVFLLVVLATTVVS----- O1.3 precursor (2951) -------MFTVFLLVVLSTTVVSS---- P1.10 precursor (3004) -------MFTVFLLVVLVTTVVS----- PIA precursor (3011) -------MFTVFLLVVLATTVGS----- PIVA precursor (4222) -------MFTVFLLVVLATTVV------ Pn1.1 precursor (2916) -------MFTVFLLVVLATTVIS----- Pn1.2 precursor (2918) -------MFTVFLLVVLATTVVS----- PnIB precursor (36) MGMRM--MFTVFLLVVLATTVVS----- PnMGMR-02 precursor (37) MGMRM--MFTVFLLVVLATTVVS----- Pu1.1 precursor (542) MGMRM--MFTVFLLVVLATTVVSFTS-- Pu1.4 precursor (2863) -------MFTVFLLVVLATTVVS----- Pu1.5 precursor (2865) -------MFTVFLLVILATTVVP----- Pu1.6 precursor (2867) -------MFTVFLLVVLVT--------- Pu14.1 precursor (3761) MGMRM--MFAVFLLVVLATTVVS----- Pu14.2 precursor (3760) MGMRM--MFTVFLLVVLATTVDS----- Pu14.3 precursor (3759) MGMRM--MFTVFLLVVLATTVDS----- Qc1.1a precursor (117) MGMRM--MFTMFLLVVLAITVVSFTS-- Qc1.1b precursor (551) MGMRM--MFTMFLLVVLAITVVSFTS-- Qc1.2 precursor (118) MGMRM--MFTVFLLVALATTVASFTL-- Qc1.4 precursor (125) MGMRM--MFTVFLLVVLATTVTS----- QcaL-1 precursor (548) MGMRM--MFTMFLLVVLATTVVSIN--- Qcal-2 precursor (549) MGMRM--MFTMFLLVVLATTVVSFN--- R1.1 precursor (2977) -------MFTVFLLVVLTITVVS----- R1.2 precursor (2979) -------MFTVFLLVVLATTVVS----- R1.3 precursor (2997) -------MFTVFLLVVLATTVVS----- RegIIA precursor (5529) MGMRM--MFTVFLLVVLTTTVVSS---- S1.1 precursor (12) MGMRM--MFTVFLLVVLAITVVS----- S1.8 precursor (3958) -------MFTVFLLVVLATTVV------ S1.9 precursor (3959) -------MFTVFLLVVLATTVV------ SI precursor (76) MGMRM--MFTVFLLVVLATTVVS----- SII precursor (91) MGMRM--MFTVFLLVVLATTVVSFPS-- SII precursor (3954) -------MFTVFLLVVLTTTVV------ SII precursor (3900) MGMRM--MFTVFLLVVLATTVVS----- SII precursor (9) MGMRM--MFTVFLLVVLATTVVS----- SIVA precursor (3960) -------MFTVFLLVVLATNVV------ SIVA precursor (94) MGMRM--MFTVFLLVVLATTVVS----- SIVB precursor (2523) MGMRM--MFTVFLSVVLATTVVSTPS-- Sm1.1 precursor (2981) -------MFTVFLLVVLATTVVS----- Sm1.2 precursor (2920) -------MFTVFLLVVLATTVVS----- Sm1.3 precursor (2904) -------MFTVFLLVVLATTVVS----- Sm4.2 precursor (3952) -------MFTVFLLVVLATTVV------ SmIVA precursor (21) MGMRM--MFTVFLLVVLATTVVS----- SmIVB precursor (2528) MGMRM--MFTVFLLVVLATTVVSIPS-- Sp1.1 precursor (2927) -------MSTVFLLVVLATTVVS----- Sp1.2 precursor (2929) -------MFTVFLLVVLATTVAS----- SrIA/SrIB precursor (3751) MGMRM--MFTVFLLVVLATTVVS----- Su1.1 precursor (2892) -------MFTVFLLVVLATTVVS----- Su1.2 precursor (2894) -------MFTVFLLVVLATTVVS----- Su1.3 precursor (2896) -------MFTVFLLVVLATTVVS----- Su1.4 precursor (2898) -------MFTVFLLVVLATTVVS----- Su1.5 precursor (2900) -------MFTVFLLVLLATTVVS----- Su1.6 precursor (3006) -------MFTVFLLVVLATTVVP----- Su1.7 precursor (3008) -------MFTVFLLVVLATTVVS----- Su1.8 precursor (3010) -------MFTVFLLVVLATTVVS----- Sx4.1 precursor (3961) -------MFTVFLLVVLATTVV------ T1.1 precursor (2888) -------MFTVFLLVVLATTVVS----- T1.2 precursor (2890) -------MFTVFLLVVLATTVVS----- Tx1 precursor (2880) -------MFTVFLLVVLATTVVSFSSG- Tx1 precursor (52) MGMRM--MFVVFLLVVLASTVVS----- Tx1.2 precursor (2884) -------MFTVFLLVVLATTVVSFTSG- Tx1.3 precursor (2886) -------MFTVFLLVVLATTVVSFTSG- Tx2 precursor (53) MGMRM--MFTVFLLVVLATTVVS----- TxIA precursor (2882) -------MFTVFLLVVLATAVVS----- Vc1.2 precursor (4199) MGMRM--MFTVFLLVVLATTVVFFTSDR Vc1.3 precursor (4201) MGMRM--MFTVFLLVVLATTVVSFTS-- VcIA precursor (499) MGMRM--MFTVFLLVVLATTVVSSTSG- Vi1.6 precursor (4567) MGMRM--MFVVFLLVVFASSVTL----- Vi1.7 precursor (4547) MGMRM--MFTVFLLVVLATTVV------ Vt1.23 precursor (4062) MGMRM--MFTVFLLVVLATTVI------ Vt1.24 precursor (4064) MGMRM--MFTVFLLVVLATTVV------ Vt1.27 precursor (4063) MGMRM--MFTVFLLVVLATTVV------ putative peptide precursor (77) --MGMRMMFTVFLLVVLATTVVPITLA-
Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6
ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.
The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).
Contacts:
David Craik
Quentin Kaas
Last updated: Sunday 19 May 2013