TxIB[C1Xch,C3Xch] (P09987) Protein Card

General Information
Name TxIB[C1Xch,C3Xch] (named by ConoServer)
Alternative name(s) TxIB[1,3]-o,m,p
Organism synthetic construct
Protein Type Synthetic
Parent TxIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
G(Xch)CSDPP(Xch)RNKHPDLC(nh2)
Modified residues
positionsymbolname
2XchXylene cystine [half]
8XchXylene cystine [half]
17nh2C-term amidation
Average Mass 1846.14
Monoisotopic Mass 1844.76
Isoelectric Point 7.52
Extinction Coefficient [280nm] 250.00

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationRef
α6/α3β2β3R. norvegicus(TxIB[1-3]-o)42.2+/-3.3100 uMZhang,B. et al. (2021)
(TxIB[1-3]-p)20.0+/-3.3100 uMZhang,B. et al. (2021)
(TxIB[1-3]-m)14.4+/-5.6100 uMZhang,B. et al. (2021)

References
Zhang,B., Ren,M., Xiong,Y., Li,H., Wu,Y., Fu,Y., Zhangsun,D., Dong,S. and Luo,S. (2021) Cysteine [2,4] Disulfide Bond as a New Modifiable Site of α-Conotoxin TxIB. Mar Drugs 19

Internal links
Nucleic acids
Structure

External links

Tools