Cal14.1a (P09042) Protein Card

General Information
Name Cal14.1a
Organism Conus californicus
Organism region Eastern Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor Cal14.1a precursor (9043)
Notes Oroz-Parra et al., 2019 reported that Cal14.1a (27 μM) reduct H1299 lung cancer cells viability after 24 hours treatment. Cal14.1a induces a high Bax/Bcl-2 ratio, which suggests that Cal14.1a can activate apoptosis in H1299 cells.

Conopeptide class conotoxin
Gene superfamily L superfamily
Cysteine framework XIV
Pharmacological family

Sequence evidence nucleic acid level
Average Mass 1847.13
Monoisotopic Mass 1845.75
Isoelectric Point 10.42
Extinction Coefficient [280nm] 5500.00

Biggs,J.S., Watkins,M., Puillandre,N., Ownby,J.P., Lopez-Vera,E., Christensen,S., Moreno,K.J., Bernaldez,J., Licea-Navarro,A. and Olivera,B.M. (2010) Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. Mol. Phylogenet. Evol. 56:1-12
Oroz-Parra,I., Álvarez-Delgado,C., Cervantes-Luevano,K., Dueñas-Espinoza,S. and Licea-Navarro,A.F. (2019) Proapoptotic Index Evaluation of Two Synthetic Peptides Derived from the Coneshell Californiconus californicus in Lung Cancer Cell Line H1299 Mar Drugs 18:10

Internal links
Protein Precursor Cal14.1a precursor (9043)
Nucleic acids

External links