Conorphin-T[bead] (P08846) Protein Card

General Information
Name Conorphin-T[bead] (named by ConoServer)
Alternative name(s) 1(1-2,3-4)
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Conorphin-T precursor (6097)
Conorphin-T precursor (646)
Conorphin-T precursor (1678)

Classification
Conopeptide class conorphin
Gene superfamily T superfamily
Cysteine framework V
Pharmacological family

Sequence
NCCRRQICC(nh2)
Modified residues
positionsymbolname
10nh2C-term amidation
Sequence evidence protein level
Average Mass 1093.32
Monoisotopic Mass 1092.42
Isoelectric Point 12.50
Extinction Coefficient [280nm] NA

Activity

EC50: Opioid receptors

TargetOrganismEC50Ref
κsynthetic construct(ERK 1/2 phosphorylation assay)9848 nM+/-3272Brust,A. et al. (2016)
(cAMP inhibition assay)9446 nM+/-403Brust,A. et al. (2016)

Ki: Opioid receptors

TargetOrganismKiCompetitorAgonistRef
κsynthetic construct80.4 nM+/-42.6Brust,A. et al. (2016)

References
Brust,A., Croker,D.E., Colless,B., Ragnarsson,L., Andersson,A., Jain,K., Garcia-Caraballo,S., Castro,J., Brierley,S.M., Alewood,P.F., Lewis,R.J. (2016) Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J Med Chem

Internal links
Protein Precursor Conorphin-T precursor (6097)
Conorphin-T precursor (646)
Conorphin-T precursor (1678)
Nucleic acids
Structure

External links

Tools