Asi14.1 (P08781) Protein Card

General Information

Name	Asi14.1 (named by ConoServer)
Alternative name(s)	Asi14a
Organism	Conus asiaticus
Organism region	Indo-Pacific
Organism diet	vermivorous
Protein Type	Wild type
Notes	Lebbe et al 2016 reported that no activity of Asi14a against 29 Gram-negative, 10 Gram-positive bacterial strains and two yeast strains.

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	XIV
Pharmacological family

Sequence

SCGYPCSHCGIPGCYPG(nh2)
Modified residues	position symbol name 18 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	1695.91
Monoisotopic Mass	1694.61
Isoelectric Point	8.15
Extinction Coefficient [280nm]	2980.00

Activity

Percentage inhibition: Voltage-Gated Potassium Channels

Target	Organism	% inhibition		Concentration	Ref
Kv1.1	R. norvegicus	0		10 µM	Lebbe,E.K. et al. (2016)
Kv1.2	R. norvegicus	0		10 µM	Lebbe,E.K. et al. (2016)
Kv1.3	H. sapiens	0		10 µM	Lebbe,E.K. et al. (2016)
Kv1.4	R. norvegicus	0		10 µM	Lebbe,E.K. et al. (2016)
Kv1.5	R. norvegicus	0		10 µM	Lebbe,E.K. et al. (2016)
Kv1.6	R. norvegicus	0		10 µM	Lebbe,E.K. et al. (2016)

Percentage inhibition: Nicotinic acetylcholine receptors

Target	Organism	% inhibition		Concentration	Ref
α1β1δε	R. norvegicus	0		5 µM	Lebbe,E.K. et al. (2016)
α3β4	H. sapiens	0		5 µM	Lebbe,E.K. et al. (2016)
α4β4	H. sapiens	0		5 µM	Lebbe,E.K. et al. (2016)
α7	G. gallus	0		5 µM	Lebbe,E.K. et al. (2016)

References

Lebbe,E.K., Ghequire,M.G., Peigneur,S., Mille,B.G., Devi,P., Ravichandran,S., Waelkens,E., D Souza,L., De Mot,R. and Tytgat,J. (2016) Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. Mar Drugs 14

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Friday 29 September 2023