MrIA amidated [O12P] (P08774) Protein Card

General Information
Name MrIA amidated [O12P] (named by ConoServer)
Organism synthetic construct
Protein Type Synthetic
Parent MrIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family chi conotoxin

Sequence
NGVCCGYKLCHPC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Sequence evidence protein level
Average Mass 1391.65
Monoisotopic Mass 1390.54
Isoelectric Point 9.95
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Monoamine transporter

TargetOrganismIC50Ref
NETH. sapiens(IC50 calculated from reported pIC50)1.3 uMZiegman et al. (2019)
Unknown615 nMSharpe,I.A. et al. (2001)

References
Sharpe,I.A., Gehrmann,J., Loughnan,M.L., Thomas,L., Adams,D.A., Atkins,A., Palant,E., Craik,D.J., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2001) Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter Nat. Neurosci. 4:902-907
Ziegman, R., Brust, A., Jha, P., Cardoso, F.C., Lewis, R.J. and Alewood, P.F. (2019) ‘Messy’Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency Marine drugs 17:165

Internal links
Nucleic acids
Structure

External links

Tools