MrIA amidated [N1Z,del10-13] (P08710) Protein Card

General Information

Name	MrIA amidated [N1Z,del10-13] (named by ConoServer)
Organism	synthetic construct
Protein Type	Synthetic
Parent	MrIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Pharmacological family

Sequence

ZGVCCGYKL(nh2)
Modified residues	position symbol name 1 Z Pyroglutamic acid 10 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	950.13
Monoisotopic Mass	949.41
Isoelectric Point	NA
Extinction Coefficient [280nm]	NA

Activity

IC50: Monoamine transporter

Target	Organism	IC50		Ref
NET	H. sapiens	32 uM		Ziegman et al. (2019)

References

Ziegman, R., Brust, A., Jha, P., Cardoso, F.C., Lewis, R.J. and Alewood, P.F. (2019) ‘Messy’Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency Marine drugs 17:165

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Monday 2 October 2023