TxID[S9K] (P08425) Protein Card

General Information
Name TxID[S9K]
Organism synthetic construct
Protein Type Synthetic
Parent TxID

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family

Sequence
GCCSHPVCKAMSPIC(nh2)
Modified residues
positionsymbolname
16nh2C-term amidation
Average Mass 1530.87
Monoisotopic Mass 1529.61
Isoelectric Point 10.45
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α1β1δεM. musculus>10 μMAch (10 uM)Yu et al. (2018)
α2β2R. norvegicus>10 μMAch (100 uM)Yu et al. (2018)
α2β4R. norvegicus>10 μMAch (100 uM)Yu et al. (2018)
α3β2R. norvegicus>10 μMAch (100 uM)Yu et al. (2018)
α3β4R. norvegicus6.9 nM[5.3-8.9]0.9Ach (100 uM)Yu et al. (2018)
α4β2R. norvegicus>10 μMAch (100 uM)Yu et al. (2018)
α4β4R. norvegicus>10 μMAch (100 uM)Yu et al. (2018)
α6/α3β4R. norvegicus>10 μMAch (100 uM)Yu et al. (2018)
α7R. norvegicus>10 μMAch (200 uM)Yu et al. (2018)
α9α10R. norvegicus>10 μMAch (10 uM)Yu et al. (2018)

References
Yu, J., Zhu, X., Harvey, P.J., Kaas, Q., Zhangsun, D., Craik, D.J. and Luo, S. (2018) Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist Journal of medicinal chemistry 61:9256-9265

Internal links
Nucleic acids
Structure

External links

Tools