TxID[S9R] (P08422) Protein Card

General Information
Name TxID[S9R]
Organism synthetic construct
Protein Type Synthetic
Parent TxID

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family

Sequence
GCCSHPVCRAMSPIC(nh2)
Modified residues
positionsymbolname
16nh2C-term amidation
Average Mass 1558.88
Monoisotopic Mass 1557.61
Isoelectric Point 11.16
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β4R. norvegicus5.4 nM[4-7.3]1.1Ach (100 uM)Yu et al. (2018)
α6/α3β4R. norvegicus359 nM[230-530]0.6Ach (100 uM)Yu et al. (2018)

References
Yu, J., Zhu, X., Harvey, P.J., Kaas, Q., Zhangsun, D., Craik, D.J. and Luo, S. (2018) Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist Journal of medicinal chemistry 61:9256-9265

Internal links
Nucleic acids
Structure

External links

Tools