TxID[S9F] (P08420) Protein Card

General Information
Name TxID[S9F]
Organism synthetic construct
Protein Type Synthetic
Parent TxID

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family

Sequence
GCCSHPVCFAMSPIC(nh2)
Modified residues
positionsymbolname
16nh2C-term amidation
Average Mass 1549.87
Monoisotopic Mass 1548.58
Isoelectric Point 8.31
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α2β4R. norvegicus320 nM[250-410]0.9Ach (100 uM)Yu et al. (2018)
α3β4R. norvegicus11 nM[8.4-14]1.8Ach (100 uM)Yu et al. (2018)
α4β4R. norvegicus1730 nM[1410-2130]1.3Ach (100 uM)Yu et al. (2018)
α6/α3β4R. norvegicus10 nM[8.5-12]1.9Ach (100 uM)Yu et al. (2018)

References
Yu, J., Zhu, X., Harvey, P.J., Kaas, Q., Zhangsun, D., Craik, D.J. and Luo, S. (2018) Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist Journal of medicinal chemistry 61:9256-9265

Internal links
Nucleic acids
Structure

External links

Tools