MrIA [N1Z, C4(Hcy), C5(Hcy), C10(Hcy), C13(Hcy)] (P07639) Protein Card

General Information

Name	MrIA [N1Z, C4(Hcy), C5(Hcy), C10(Hcy), C13(Hcy)] (named by ConoServer)
Organism	synthetic construct
Protein Type	Patent
Parent	MrIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	X
Pharmacological family	chi conotoxin

Sequence

ZGV(Hcy)(Hcy)GYKL(Hcy)HO(Hcy)(nh2)
Modified residues	position symbol name 1 Z Pyroglutamic acid 4 Hcy Homocysteine 5 Hcy Homocysteine 10 Hcy Homocysteine 12 O 4-Hydroxyproline 13 Hcy Homocysteine 14 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	1464.79
Monoisotopic Mass	1463.62
Isoelectric Point	NA
Extinction Coefficient [280nm]	NA

Activity

IC50: Monoamine transporter

Target	Organism	IC50		Competitor	Ref
NET	H. sapiens	>100uM		[3H]nisoxetine 4.3 nM	Brust,A. et al. (2009)

References

Brust,A., Palant,E., Croker,D.E., Colless,B., Drinkwater,R., Patterson,B., Schroeder,C.I., Wilson,D., Nielsen,C.K., Smith,M.T., Alewood,D., Alewood,P.F. and Lewis,R.J. (2009) chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. J. Med. Chem. 52:6991-7002

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Monday 2 October 2023