MrIA [N1Z,H11(Fla)] (P07616) Protein Card

General Information

Name	MrIA [N1Z,H11(Fla)] (named by ConoServer)
Organism	synthetic construct
Protein Type	Synthetic
Parent	MrIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	X
Pharmacological family	chi conotoxin

Sequence

ZGVCCGYKLC(FLA)OC(nh2)

Modified residues

position	symbol	name
1	Z	Pyroglutamic acid
11	FLA	L-2-furylalanine
12	O	4-Hydroxyproline
14	nh2	C-term amidation

Sequence evidence

protein level

Average Mass

1404.64

Monoisotopic Mass

1403.51

Isoelectric Point

Extinction Coefficient [280nm]

Activity

IC50: Monoamine transporter

Target	Organism	IC50		Competitor	Ref
NET	H. sapiens	14.8 uM		[3H]nisoxetine 4.3 nM	Brust,A. et al. (2009)

References

Brust,A., Palant,E., Croker,D.E., Colless,B., Drinkwater,R., Patterson,B., Schroeder,C.I., Wilson,D., Nielsen,C.K., Smith,M.T., Alewood,D., Alewood,P.F. and Lewis,R.J. (2009) chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. J. Med. Chem. 52:6991-7002

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Monday 2 October 2023