Con-ins G1 A Chain[C6U,C11U] (P06939) Protein Card

General Information
Name Con-ins G1 A Chain[C6U,C11U] (named by ConoServer)
Alternative name(s) sCon-Ins G1
Organism synthetic construct
Protein Type Synthetic
Parent Con-ins G1 A chain
Notes Safavi-Hemami et al., 2015 reported that U6 and U11 form disulfide bridges with B chain. Synthetic insulin dimers reduced blood glucose and swimming activity in zebrafish.

Classification
Conopeptide class coninsulin
Gene superfamily Insulin superfamily
Pharmacological family

Sequence
GVVEH(Sec)CHRP(Sec)SNAEFKKYCG
Modified residues
positionsymbolname
6SecSelenocysteine
11SecSelenocysteine
Sequence evidence protein level
Average Mass 2330.29
Monoisotopic Mass 2453.91
Isoelectric Point 8.59
Extinction Coefficient [280nm] 1740.00

References
Safavi-Hemami,H., Gajewiak,J., Karanth,S., Robinson,S.D., Ueberheide,B., Douglass,A.D., Schlegel,A., Imperial,J.S., Watkins,M., Bandyopadhyay,P.K., Yandell,M., Li,Q., Purcell,A.W., Norton,R.S., Ellgaard,L. and Olivera,B.M. (2015) Specialized insulin is used for chemical warfare by fish-hunting cone snails. Proc. Natl. Acad. Sci. U.S.A. 112:1743-1748

Internal links
Nucleic acids
Structure

External links

Tools