TxVA precursor (P00645) Protein Card

General Information
Name TxVA precursor
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Precursor

Conopeptide class conotoxin
Gene superfamily T superfamily
Pharmacological family

Sequence region
[1-19]signal sequence
[51-63]mature peptideTxVA

Conticello,S.G., Gilad,Y., Avidan,N., Ben-Asher,E., Levy,Z. and Fainzilber,M. (2001) Mechanisms for evolving hypervariability: the case of conopeptides Mol. Biol. Evol. 18:120-131
Kalume,D.E., Stenflo,J., Czerwiec,E., Hambe,B., Furie,B.C., Furie,B. and Roepstorff,P. (2000) Structure determination of two conotoxins from Conus textile by a combination of matrix-assisted laser desorption/ionization time-of-flight and electrospray ionization mass spectrometry and biochemical methods J Mass Spectrom 35:145-156
Walker,C.S., Steel,D., Jacobsen,R.B., Lirazan,M.B., Cruz,L.J., Hooper,D., Shetty,R., DelaCruz,R.C., Nielsen,J.S., Zhou,L.M., Bandyopadhyay,P., Craig,A.G. and Olivera,B.M. (1999) The T-superfamily of conotoxins J. Biol. Chem. 274:30664-30671
Rigby,A.C., Lucas-Meunier,E., Kalume,D.E., Czerwiec,E., Hambe,B., Dahlqvist,I., Fossier,P., Baux,G., Roepstorff,P., Baleja,J.D., Furie,B.C., Furie,B. and Stenflo,J. (1999) A conotoxin from Conus textile with unusual posttranslational modifications reduces presynaptic Ca2+ influx Proc. Natl. Acad. Sci. U.S.A. 96:5758-5763
Bush,K.A., Stenflo,J., Roth,D.A., Czerwiec,E., Harrist,A., Begley,G.S., Furie,B.C. and Furie,B. (1999) Hydrophobic amino acids define the carboxylation recognition site in the precursor of the gamma-carboxyglutamic-acid-containing conotoxin epsilon-TxIX from the marine cone snail Conus textile. Biochemistry 38:14660-14666

Internal links
Nucleic acids Conus textile clone TxMRCL-012 conotoxin scaffold IX precursor, mRNA, complete cds
Tau-conotoxin peptides
Sequence 30 from patent US 6630573
Sequence 32 from patent US 6630573

External links
UniProtKB/Swiss-Prot P81755
Ncbi P81755, AAG60386