Mr14.6 (P05411) Protein Card

General Information
Name Mr14.6
Alternative name(s) Mr027
Organism Conus marmoreus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor Mr14.6 precursor (5410)
Notes The peptide mass was found by MS but it was not sequenced by MS/MS (Dutertre 2013). There is an ambiguity regarding which Glu is modified into a gamma-carboxylic Glu.

Classification
Conopeptide class conotoxin
Gene superfamily I2 superfamily
Cysteine framework XIV
Pharmacological family

Sequence
LCDSYISS(Gla)LC(Gla)HP(Gla)ETCLLPQSYVLSVE
SIQTGSVYVLEACRIFTKTS(nh2)
Modified residues
positionsymbolname
9GlaGamma carboxylic glutamic acid
12GlaGamma carboxylic glutamic acid
15GlaGamma carboxylic glutamic acid
50nh2C-term amidation
Sequence evidence protein level
Average Mass 5600.20
Monoisotopic Mass 5596.55
Isoelectric Point 4.92
Extinction Coefficient [280nm] 4470.00

References
Dutertre,S., Jin,A.H., Kaas,Q., Jones,A., Alewood,P.F. and Lewis,R.J. (2013) Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Mol. Cell Proteomics 12:312-329

Internal links
Protein Precursor Mr14.6 precursor (5410)
Nucleic acids
Structure

External links

Tools