Cal14.1b (P04159) Protein Card

General Information
Name Cal14.1b
Organism Conus californicus
Organism region Eastern Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor Cal14.1b precursor (4016)
Notes

Zazueta-Favela et al., 2019 reported that Cal14.1b increased intracellular IL-10 production in Treg (CD3+CD4+Foxp3+) cells and decreased intracellular IL-17 production after 72h of culture. Cal14.1b did not show any effect on T cell proliferation nor on Th1/Th2 balance.

Oroz-Parra et al., 2019 reported that Cal14.1b (27 μM) reduct H1299 lung cancer cells viability after 24 hours treatment. But Cal14.1b does not increase the Bax/Bcl-2 ratio.

Classification
Conopeptide class conotoxin
Gene superfamily L superfamily
Cysteine framework XIV
Pharmacological family

Sequence
GDCPPWCVGARCRAGKC
Sequence evidence nucleic acid level
Average Mass 1775.06
Monoisotopic Mass 1773.73
Isoelectric Point 11.63
Extinction Coefficient [280nm] 5500.00

References
Biggs,J.S., Watkins,M., Puillandre,N., Ownby,J.P., Lopez-Vera,E., Christensen,S., Moreno,K.J., Bernaldez,J., Licea-Navarro,A. and Olivera,B.M. (2010) Evolution of Conus peptide toxins: analysis of Conus californicus Reeve, 1844. Mol. Phylogenet. Evol. 56:1-12
Zazueta-Favela,D., Donis-Maturano,L., Licea-Navarro,A.F., Bernáldez-Sarabia,J., Dan,K.W.L., Cota-Arce,J.M., Escobedo,G. and De León-Nava,M.A. (2019) Marine peptides as immunomodulators: Californiconus californicus-derived synthetic conotoxins induce IL-10 production by regulatory T cells (CD4+Foxp3+) Immunopharmacol Immunotoxicol 41:463-468
Oroz-Parra,I., Álvarez-Delgado,C., Cervantes-Luevano,K., Dueñas-Espinoza,S. and Licea-Navarro,A.F. (2019) Proapoptotic Index Evaluation of Two Synthetic Peptides Derived from the Coneshell Californiconus californicus in Lung Cancer Cell Line H1299 Mar Drugs 18:10

Internal links
Protein Precursor Cal14.1b precursor (4016)
Nucleic acids
Structure

External links

Tools