Cyclic MrIA (P02848) Protein Card

General Information

Name	Cyclic MrIA
Organism	synthetic construct
Protein Type	Synthetic
Parent	MrIA

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	X
Pharmacological family	chi conotoxin

Sequence

NGVCCGYKLCHOCAG
Modified residues	position symbol name 12 O 4-Hydroxyproline
Average Mass	1518.75
Monoisotopic Mass	1517.57
Isoelectric Point	10.45
Extinction Coefficient [280nm]	1490.00

References

Lovelace,E.S., Armishaw,C.J., Colgrave,M.L., Wahlstrom,M.E., Alewood,P.F., Daly,N.L. and Craik,D.J. (2006) Cyclic MrIA: a stable and potent cyclic conotoxin with a novel topological fold that targets the norepinephrine transporter J. Med. Chem. 49:6561-6568

Internal links

Nucleic acids
Structure	CYCLIC MRIA: AN EXCEPTIONALLY STABLE AND POTENT CYCLIC CONOTOXIN WITH A NOVEL TOPOLOGICAL FOLD THAT TARGETS THE NOREPINEPHRINE TRANSPORTER.

External links

Ncbi

2J15_A

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Monday 2 October 2023