PrIIIE (P02832) Protein Card

General Information

Name	PrIIIE
Alternative name(s)	Pr3.5,Pr3e
Organism	Conus parius
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Wild type
Protein precursor	PrIIIE precursor (2831)

Classification

Conopeptide class	conotoxin
Gene superfamily	M superfamily
Cysteine framework	III
Pharmacological family	alpha conotoxin

Sequence

AARCCTYHGSCLKEKCRRKYCC(nh2)
Modified residues	position symbol name 23 nh2 C-term amidation
Sequence evidence	nucleic acid level
Average Mass	2576.05
Monoisotopic Mass	2574.11
Isoelectric Point	11.33
Extinction Coefficient [280nm]	2980.00

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Agonist	Ref
α1β1δε	M. musculus	245nM		100uM Ach	Lluisma,A.O. et al. (2008)
α1β1γδ	A. honmai NPV	3.2uM		100uM Ach	Favreau,P. ()

References

Lluisma,A.O., López-Vera,E., Bulaj,G., Watkins,M. and Olivera,B.M. (2008) Characterization of a novel psi-conotoxin from Conus parius Reeve. Toxicon 51:174-180

Internal links

Protein Precursor	PrIIIE precursor (2831)
Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Friday 29 September 2023