RXIC (P02592) Protein Card

General Information
Name RXIC
Alternative name(s) R11.4,R11c
Organism Conus radiatus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor RXIC precursor (1409)
Notes The mutation l42>L leads to almost no loss of activity in amphibian axons, contrary to the modification of the d-amino acids of RXIA which leads to a loss of activity (Buczek et al 2005).

Classification
Conopeptide class conotoxin
Gene superfamily I1 superfamily
Cysteine framework XI
Pharmacological family

Sequence
GOSFCKADEKOCKYHADCCNCCLGGICKOSTSWIGCSTNVF
lT
Modified residues
positionsymbolname
2O4-Hydroxyproline
11O4-Hydroxyproline
29O4-Hydroxyproline
42lD-leucine
Sequence evidence protein level
Average Mass 4629.24
Monoisotopic Mass 4625.90
Isoelectric Point 9.68
Extinction Coefficient [280nm] 6990.00

References
Buczek,O., Yoshikami,D., Watkins,M., Bulaj,G., Jimenez,E.C. and Olivera,B.M. (2005) Characterization of D-amino-acid-containing excitatory conotoxins and redefinition of the I-conotoxin superfamily FEBS J. 272:4178-4188
Jimenez,E.C., Shetty,R.P., Lirazan,M., Rivier,J., Walker,C., Abogadie,F.C., Yoshikami,D., Cruz,L.J. and Olivera,B.M. (2003) Novel excitatory Conus peptides define a new conotoxin superfamily J. Neurochem. 85:610-621

Internal links
Protein Precursor RXIC precursor (1409)
Nucleic acids Conus radiatus I-superfamily conotoxin R11.4 (R11.4) mRNA, partial cds
Structure

External links
Ncbi Q7Z096, AAP41539

Tools