RIIIK (P02591) Protein Card

General Information
Name RIIIK
Alternative name(s) R3.1,R3k
Organism Conus radiatus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor RIIIK precursor (1521)

Classification
Conopeptide class conotoxin
Gene superfamily M superfamily
Cysteine framework III
Pharmacological family kappa conotoxin

Sequence
LOSCCSLNLRLCOVOACKRNOCCT(nh2)
Modified residues
positionsymbolname
2O4-Hydroxyproline
13O4-Hydroxyproline
15O4-Hydroxyproline
21O4-Hydroxyproline
25nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 2649.14
Monoisotopic Mass 2647.16
Isoelectric Point 12.54
Extinction Coefficient [280nm] NA

Activity

IC50: Voltage-Gated Potassium Channels

TargetOrganismIC50Ref
Kv1.2O. mykiss73nM+/-34Al-Sabi,A. et al. (2004)

Synthetic variants
Ac-L1(Ac)LOSCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [K18A]LOSCCSLNLRLCOVOACARNOCCT(nh2)
RIIIK [K18R, R19K]LOSCCSLNLRLCOVOACRKNOCCT(nh2)
RIIIK [L11A]LOSCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [L1A]AOSCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [L1E]EOSCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [L1F]FOSCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [L1H]HOSCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [L1I]IOSCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [L1K]KOSCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [L1M]MOSCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [L1R]ROSCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [L1Y]YOSCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [L7A]LOSCCSANLRLCOVOACKRNOCCT(nh2)
RIIIK [L9A]LOSCCSLNARLCOVOACKRNOCCT(nh2)
RIIIK [N20A]LOSCCSLNLRLCOVOACKRAOCCT(nh2)
RIIIK [N8A]LOSCCSLALRLCOVOACKRNOCCT(nh2)
RIIIK [O13A]LOSCCSLNLRLCAVOACKRNOCCT(nh2)
RIIIK [O15A]LOSCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [O21A]LOSCCSLNLRLCOVOACKRNACCT(nh2)
RIIIK [O2A]LASCCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [R10A]LOSCCSLNLALCOVOACKRNOCCT(nh2)
RIIIK [R19A]LOSCCSLNLRLCOVOACKANOCCT(nh2)
RIIIK [S3A]LOACCSLNLRLCOVOACKRNOCCT(nh2)
RIIIK [S6A]LOSCCALNLRLCOVOACKRNOCCT(nh2)
RIIIK [T24A]LOSCCSLNLRLCOVOACKRNOCCA(nh2)
RIIIK [V14A]LOSCCSLNLRLCOAOACKRNOCCT(nh2)
RIIIKΔ9LOSCCSLNLRLCOVOACKRNOCCT(nh2)

References
Corpuz,G.P., Jacobsen,R.B., Jimenez,E.C., Watkins,M., Walker,C., Colledge,C., Garrett,J.E., McDougal,O., Li,W., Gray,W.R., Hillyard,D.R., Rivier,J., McIntosh,J.M., Cruz,L.J. and Olivera,B.M. (2005) Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms Biochemistry 44:8176-8186
Ferber,M., Sporning,A., Jeserich,G., DeLaCruz,R., Watkins,M., Olivera,B.M. and Terlau,H. (2003) A novel conus peptide ligand for K+ channels J. Biol. Chem. 278:2177-2183
Al-Sabi,A., Lennartz,D., Ferber,M., Gulyas,J., Rivier,J.E., Olivera,B.M., Carlomagno,T. and Terlau,H. (2004) KappaM-conotoxin RIIIK, structural and functional novelty in a K+ channel antagonist. Biochemistry 43:8625-8635

Internal links
Protein Precursor RIIIK precursor (1521)
Nucleic acids
Structure

External links
Ncbi P69769

Tools