Tx3a (P02560) Protein Card

General Information
Name Tx3a
Alternative name(s) Tx3.2,TxIIIA
Organism Conus textile (Cloth-of-gold cone)
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor TxIIIA precursor (640)
Notes The Swiss-Prot card states that the C-terminus is partially amidated but Corpuz et al 2005 and Han et al 2006 described a free C-terminal acid. Finally Ueberheide et al. 2009 published the isolation of both form from the same venom.

Conopeptide class conotoxin
Gene superfamily M superfamily
Cysteine framework III
Pharmacological family

Modified residues
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1711.89
Monoisotopic Mass 1710.48
Isoelectric Point 4.50
Extinction Coefficient [280nm] 5500.00

Conticello,S.G., Gilad,Y., Avidan,N., Ben-Asher,E., Levy,Z. and Fainzilber,M. (2001) Mechanisms for evolving hypervariability: the case of conopeptides Mol. Biol. Evol. 18:120-131
Corpuz,G.P., Jacobsen,R.B., Jimenez,E.C., Watkins,M., Walker,C., Colledge,C., Garrett,J.E., McDougal,O., Li,W., Gray,W.R., Hillyard,D.R., Rivier,J., McIntosh,J.M., Cruz,L.J. and Olivera,B.M. (2005) Definition of the M-conotoxin superfamily: characterization of novel peptides from molluscivorous Conus venoms Biochemistry 44:8176-8186
Han,Y.H., Wang,Q., Jiang,H., Liu,L., Xiao,C., Yuan,D.D., Shao,X.X., Dai,Q.Y., Cheng,J.S. and Chi,C.W. (2006) Characterization of novel M-superfamily conotoxins with new disulfide linkage FEBS J. 273:4972-4982
Ueberheide,B.M., Fenyö,D., Alewood,P.F. and Chait,B.T. (2009) Rapid sensitive analysis of cysteine rich peptide venom components. Proc. Natl. Acad. Sci. U.S.A. 106:6910-6915
Dobson,R., Collodoro,M., Gilles,N., Turtoi,A., De Pauw,E. and Quinton,L. (2012) Secretion and maturation of conotoxins in the venom ducts of Conus textile. Toxicon 60:1370-1379
Zhou,M., Wang,L., Wu,Y., Zhu,X., Feng,Y., Chen,Z., Li,Y., Sun,D., Ren,Z. and Xu,A. (2013) Characterizing the evolution and functions of the M-superfamily conotoxins. Toxicon 76:150-159

Internal links
Protein Precursor TxIIIA precursor (640)
Nucleic acids Conus textile clone TxMLKM-012 conotoxin scaffold III/IV precursor, mRNA, complete cds

External links
Ncbi AAG60381, AAG60511, Q9BH73