Bromosleeper peptide (P01811) Protein Card

General Information

Name	Bromosleeper peptide
Organism	Conus radiatus
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Wild type
Protein precursor	Bromosleeper peptide precursor (4227)

Classification

Conopeptide class	conotoxin
Gene superfamily	O3 superfamily
Cysteine framework	VI/VII
Pharmacological family

Sequence

(Btr)ATID(Gla)C(Gla)(Gla)TCNVTFKTCCGOOGDW QCV(Gla)ACPV
Modified residues	position symbol name 1 Btr Bromotryptophan 6 Gla Gamma carboxylic glutamic acid 8 Gla Gamma carboxylic glutamic acid 9 Gla Gamma carboxylic glutamic acid 21 O 4-Hydroxyproline 22 O 4-Hydroxyproline 29 Gla Gamma carboxylic glutamic acid
Sequence evidence	protein level
Average Mass	3916.96
Monoisotopic Mass	3913.28
Isoelectric Point	1.63
Extinction Coefficient [280nm]	5500.00

References

Craig,A.G., Jimenez,E.C., Dykert,J., Nielsen,D.B., Gulyas,J., Abogadie,F.C., Porter,J., Rivier,J.E., Cruz,L.J., Olivera,B.M. and McIntosh,J.M. (1997) A novel post-translational modification involving bromination of tryptophan. Identification of the residue, L-6-bromotryptophan, in peptides from Conus imperialis and Conus radiatus venom J. Biol. Chem. 272:4689-4698

Internal links

Protein Precursor	Bromosleeper peptide precursor (4227)
Nucleic acids
Structure

External links

UniProtKB/Swiss-Prot	P58804
Ncbi	P58804

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Monday 11 December 2023