MrIB (P01737) Protein Card

General Information

Name	MrIB
Alternative name(s)	Mr1b
Organism	Conus marmoreus
Organism region	Indo-Pacific
Organism diet	molluscivorous
Protein Type	Wild type
Notes	The superfamily was assigned on the strong sequence identity with MrIA.

Classification

Conopeptide class	conotoxin
Gene superfamily	T superfamily
Cysteine framework	X
Pharmacological family	chi conotoxin

Sequence

VGVCCGYKLCHOC
Modified residues	position symbol name 12 O 4-Hydroxyproline
Sequence evidence	protein level
Average Mass	1393.67
Monoisotopic Mass	1392.54
Isoelectric Point	10.34
Extinction Coefficient [280nm]	1490.00

Synthetic variants

MrIB amidated

VGVCCGYKLCHOC(nh2)

References

Sharpe,I.A., Gehrmann,J., Loughnan,M.L., Thomas,L., Adams,D.A., Atkins,A., Palant,E., Craik,D.J., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2001) Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter Nat. Neurosci. 4:902-907

Internal links

Nucleic acids
Structure

External links

UniProtKB/Swiss-Prot	P58810
Ncbi	P58810

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 26 September 2023