VxXXC (P01684) Protein Card

General Information
Name VxXXC
Alternative name(s) VxXIIC
Organism Conus vexillum
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Notes Framework: This framework was assigned to be XII on discovery of VxXXA , VxXXB and VxXXC (previously named VxXIIA, VxXIIB and VxXIIC respectively) 2006, which also had been used for conotoxins from the I superfamily (Brown et al. 2005). Loughnan et al. now propose framework designation XX (see reference).

Dimers: Mature D superfamily peptides form hetero-, homo- and pseudohomodimers (identical sequence, different posttranslational modifications). Entries for mature peptides in ConoServer are for monomers.

The swiss-prot card describes positions 10, 21 and 29 as being hydroxyprolines which is in contradiction with Loughnan et al 2006.

The superfamily assignment is based on the strong homology with VxXXA and VxXXB.

Conopeptide class conotoxin
Gene superfamily D superfamily
Cysteine framework XX
Pharmacological family alpha conotoxin

Sequence evidence protein level
Average Mass 5276.01
Monoisotopic Mass 5272.11
Isoelectric Point 12.20
Extinction Coefficient [280nm] 13980.00

Loughnan,M., Nicke,A., Jones,A., Schroeder,C.I., Nevin,S.T., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2006) Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum J. Biol. Chem. 281:24745-24755
Loughnan,M.L., Nicke,A., Lawrence,N. and Lewis,R.J. (2009) Novel alphaD-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry 48:3717-3729

Internal links
Nucleic acids

External links
UniProtKB/Swiss-Prot P0C1W7
Ncbi P0C1W7