Am2766 (P01630) Protein Card

General Information
Name Am2766
Organism Conus amadis
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Notes Acts on rat Nav1.2 (Sudarslal et al. 2003).

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family delta conotoxin

Sequence
CKQAGESCDIFSQNCCVGTCAFICIE(nh2)
Modified residues
positionsymbolname
27nh2C-term amidation
Sequence evidence protein level
Average Mass 2766.15
Monoisotopic Mass 2764.09
Isoelectric Point 4.20
Extinction Coefficient [280nm] NA

References
Sudarslal,S., Majumdar,S., Ramasamy,P., Dhawan,R., Pal,P.P., Ramaswami,M., Lala,A.K., Sikdar,S.K., Sarma,S.P., Krishnan,K.S. and Balaram,P. (2003) Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail FEBS Lett. 553:209-212
Sarma,S.P., Kumar,G.S., Sudarslal,S., Iengar,P., Ramasamy,P., Sikdar,S.K., Krishnan,K.S. and Balaram,P. (2005) Solution structure of delta-Am2766: a highly hydrophobic delta-conotoxin from Conus amadis that inhibits inactivation of neuronal voltage-gated sodium channels. Chem. Biodivers. 2:535-556

Internal links
Nucleic acids
Structure SOLUTION STRUCTURE OF AM2766

External links
UniProtKB/Swiss-Prot P60179
Ncbi 1YZ2_A, P60179

Tools