MVIIA precursor (P01564) Protein Card

General Information
Name MVIIA precursor
Organism Conus magus (Magus cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Pharmacological family

Sequence
MKLTCVVIVAVLLLTACQLITA
DDSRGTQKHRALRSTTKLS
TSTR
CKGKGAKCSRLMYDCCTGSCRSGKC
G
Sequence region
[1-22]signal sequence
[46-70]mature peptideMVIIA

References
Olivera,B.M., Gray,W.R., Zeikus,R., McIntosh,J.M., Varga,J., Rivier,J., de Santos,V. and Cruz,L.J. (1985) Peptide neurotoxins from fish-hunting cone snails Science 230:1338-1343
Lewis,R.J., Nielsen,K.J., Craik,D.J., Loughnan,M.L., Adams,D.A., Sharpe,I.A., Luchian,T., Adams,D.J., Bond,T., Thomas,L., Jones,A., Matheson,J.L., Drinkwater,R., Andrews,P.R. and Alewood,P.F. (2000) Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes J. Biol. Chem. 275:35335-35344
Olivera,B.M., Cruz,L.J., de Santos,V., Lecheminant,G.W., Griffin,D., Zeikus,R.D., McIntosh,J.M., Galyean,R., Varga,J., Gray,W.R. and Rivier,J.E. (1987) Neuronal calcium channel antagonists. Discrimination between calcium channel subtypes using omega-conotoxin from Conus magus venom Biochemistry 26:2086-2090
Chung,D., Gaur,S., Bell,J.R., Ramachandran,J. and Nadasdi,L. (1995) Determination of disulfide bridge pattern in omega-conopeptides Int. J. Pept. Protein Res. 46:320-325
Kim,J.I., Takahashi,M., Ohtake,A., Wakamiya,A. and Sato,K. (1995) Tyr13 is essential for the activity of omega-conotoxin MVIIA and GVIA, specific N-type calcium channel blockers Biochem. Biophys. Res. Commun. 206:449-454
Miljanich,G.P. (2004) Ziconotide: neuronal calcium channel blocker for treating severe chronic pain Curr. Med. Chem. 11:3029-3040
Kohno,T., Kim,J.I., Kobayashi,K., Kodera,Y., Maeda,T. and Sato,K. (1995) Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin MVIIA Biochemistry 34:10256-10265
Basus,V.J., Nadasdi,L., Ramachandran,J. and Miljanich,G.P. (1995) Solution structure of omega-conotoxin MVIIA using 2D NMR spectroscopy FEBS Lett. 370:163-169
Nielsen,K.J., Thomas,L., Lewis,R.J., Alewood,P.F. and Craik,D.J. (1996) A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202 J. Mol. Biol. 263:297-310
Nielsen,K.J., Adams,D., Thomas,L., Bond,T., Alewood,P.F., Craik,D.J. and Lewis,R.J. (1999) Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels J. Mol. Biol. 289:1405-1421
Atkinson,R.A., Kieffer,B., Dejaegere,A., Sirockin,F. and Lefevre,J.F. (2000) Structural and dynamic characterization of omega-conotoxin MVIIA: the binding loop exhibits slow conformational exchange Biochemistry 39:3908-3919
Goldenberg,D.P., Koehn,R.E., Gilbert,D.E. and Wagner,G. (2001) Solution structure and backbone dynamics of an omega-conotoxin precursor Protein Sci. 10:538-550

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P05484
Ncbi P05484

Tools