PnIVA (P01560) Protein Card

General Information

Name	PnIVA
Alternative name(s)	Pn4a
Organism	Conus pennaceus
Organism region	Indo-Pacific
Organism diet	molluscivorous
Protein Type	Wild type
Notes	Block tetrodotoxin resistant (TTX-R) Na channels (Fainzilber et al 1995).

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	IV
Pharmacological family	mu conotoxin

Sequence

CCKYGWTCLLGCSPCGC
Sequence evidence	protein level
Average Mass	1791.12
Monoisotopic Mass	1789.62
Isoelectric Point	10.17
Extinction Coefficient [280nm]	6990.00

References

Fainzilber,M., Nakamura,T., Gaathon,A., Lodder,J.C., Kits,K.S., Burlingame,A.L. and Zlotkin,E. (1995) A new cysteine framework in sodium channel blocking conotoxins Biochemistry 34:8649-8656

Internal links

Nucleic acids
Structure

External links

UniProtKB/Swiss-Prot	P58926
Ncbi	P58926, 2116206A

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Wednesday 27 September 2023