MrVIA (P01554) Protein Card

General Information
Name MrVIA
Alternative name(s) Mr053
Organism Conus marmoreus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Protein precursor MrVIA precursor (4528)
MrVIA precursor (6268)
Notes The superfamily was assigned on the basis of the strong sequence identity with MrVIB. Block tetrodotoxin resistant (TTX-R) Na channels and the blockade is slow and reversible (Zhang et al 2006).

Conopeptide class conotoxin
Gene superfamily O1 superfamily
Cysteine framework VI/VII
Pharmacological family mu conotoxin

Sequence evidence protein level
Average Mass 3489.30
Monoisotopic Mass 3486.66
Isoelectric Point 11.12
Extinction Coefficient [280nm] 8480.00


IC50: Voltage-Gated Sodium Channels

Nav1.2R. norvegicus532nMSafo,P. et al. (2000)
Nav1.4R. norvegicus438nMSafo,P. et al. (2000)
Nav1.7R. norvegicus345nMSafo,P. et al. (2000)

McIntosh,J.M., Hasson,A., Spira,M.E., Gray,W.R., Li,W., Marsh,M., Hillyard,D.R. and Olivera,B.M. (1995) A new family of conotoxins that blocks voltage-gated sodium channels J. Biol. Chem. 270:16796-16802
Safo,P., Rosenbaum,T., Shcherbatko,A., Choi,D.Y., Han,E., Toledo-Aral,J.J., Olivera,B.M., Brehm,P. and Mandel,G. (2000) Distinction among neuronal subtypes of voltage-activated sodium channels by mu-conotoxin PIIIA J. Neurosci. 20:76-80
Fainzilber,M., van der Schors,R., Lodder,J.C., Li,K.W., Geraerts,W.P. and Kits,K.S. (1995) New sodium channel-blocking conotoxins also affect calcium currents in Lymnaea neurons Biochemistry 34:5364-5371
Zorn,S., Leipold,E., Hansel,A., Bulaj,G., Olivera,B.M., Terlau,H. and Heinemann,S.H. (2006) The muO-conotoxin MrVIA inhibits voltage-gated sodium channels by associating with domain-3 FEBS Lett. 580:1360-1364
Terlau,H., Stocker,M., Shon,K.J., McIntosh,J.M. and Olivera,B.M. (1996) MicroO-conotoxin MrVIA inhibits mammalian sodium channels, but not through site I J. Neurophysiol. 76:1423-1429
Dutertre,S., Jin,A.H., Kaas,Q., Jones,A., Alewood,P.F. and Lewis,R.J. (2013) Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Mol. Cell Proteomics 12:312-329

Internal links
Protein Precursor MrVIA precursor (4528)
MrVIA precursor (6268)
Nucleic acids

External links
UniProtKB/Swiss-Prot P56708
Ncbi P56708, AAB34917, AAB34193