PlXIVA (P01539) Protein Card

General Information
Name PlXIVA
Alternative name(s) Pl14a
Organism Conus planorbis
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor PlXIVA precursor (1183)

Classification
Conopeptide class conotoxin
Gene superfamily J superfamily
Cysteine framework XIV
Pharmacological family kappa conotoxin
alpha conotoxin

Sequence
FPRPRICNLACRAGIGHKYPFCHCR(nh2)
Modified residues
positionsymbolname
26nh2C-term amidation
Sequence evidence protein level
Average Mass 2911.49
Monoisotopic Mass 2909.42
Isoelectric Point 12.52
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Voltage-Gated Potassium Channels

TargetOrganismIC50AgonistRef
Kv1.6D. melanogaster1.59uM+/-0.96Imperial,J.S. et al. (2006)

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus540nM1-10uM AchImperial,J.S. et al. (2006)
α3β4R. norvegicus8.7uM100uM AchImperial,J.S. et al. (2006)

Percentage inhibition: Voltage-Gated Potassium Channels

TargetOrganism% inhibitionConcentrationRef
Kv1.1D. melanogaster01uMImperial,J.S. et al. (2006)
Kv1.2D. melanogaster01uMImperial,J.S. et al. (2006)
Kv1.3D. melanogaster01uMImperial,J.S. et al. (2006)
Kv1.4D. melanogaster01uMImperial,J.S. et al. (2006)
Kv1.5D. melanogaster01uMImperial,J.S. et al. (2006)

References
Imperial,J.S., Bansal,P.S., Alewood,P.F., Daly,N.L., Craik,D.J., Sporning,A., Terlau,H., Lopez-Vera,E., Bandyopadhyay,P.K. and Olivera,B.M. (2006) A novel conotoxin inhibitor of Kv1.6 channel and nAChR subtypes defines a new superfamily of conotoxins Biochemistry 45:8331-8340

Internal links
Protein Precursor PlXIVA precursor (1183)
Nucleic acids
Structure SOLUTION STRUCTURE OF CONOTOXIN PL14A

External links
Ncbi Q0N4U8, 2FQC_A, ABE27006

Tools