CMrVIA (P01537) Protein Card

General Information

Name	CMrVIA
Alternative name(s)	Mr6a
Organism	Conus marmoreus
Organism region	Indo-Pacific
Organism diet	molluscivorous
Protein Type	Wild type

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	X
Pharmacological family	chi conotoxin

Sequence

VCCGYKLCHOC
Modified residues	position symbol name 10 O 4-Hydroxyproline
Sequence evidence	protein level
Average Mass	1237.48
Monoisotopic Mass	1236.45
Isoelectric Point	9.67
Extinction Coefficient [280nm]	1490.00

Synthetic variants

CMrVIA [K6P]	VCCGYPLCHOC
CMrVIA [K6P] amidated	VCCGYPLCHOC(nh2)
CMrVIA amidated	VCCGYKLCHOC(nh2)

References

Kang,T.S., Jois,S.D. and Kini,R.M. (2006) Solution structures of two structural isoforms of CMrVIA chi/lambda-conotoxin Biomacromolecules 7:2337-2346

Balaji,R.A., Ohtake,A., Sato,K., Gopalakrishnakone,P., Kini,R.M., Seow,K.T. and Bay,B.H. (2000) lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding. Isolation and characterization from the venom of Conus marmoreus J. Biol. Chem. 275:39516-39522

Internal links

Nucleic acids
Structure	SOLUTION STRUCTURE OF RIBBON ISOFORM OF CMRVIA LAMBDA CONOTOXIN SOLUTION STRUCTURE OF GLOBULAR CONFORMATION OF CMRVIA LAMBDA CONOTOXIN

External links

Ncbi	2B5Q_A, 2B5P_A, P58807

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Wednesday 27 September 2023