Conantokin-R precursor (P01375) Protein Card

General Information
Name Conantokin-R precursor
Organism Conus radiatus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor

Classification
Conopeptide class conantokin
Gene superfamily B1 superfamily
Pharmacological family

Sequence
MQLYTYLYLLVSLVTFYLILGTGT
LGHGGALTERRSTDATA
LKPEPVLLQKSSARSTDDNGNDRLTQMKRILKKRGNKAR
GE
EEVAKMAAELARENIAKGCKVNCYP
Sequence region
[1-24]signal sequence
[81-107]mature peptideConantokin-R

References
Klein,R.C., Prorok,M., Galdzicki,Z. and Castellino,F.J. (2001) The amino acid residue at sequence position 5 in the conantokin peptides partially governs subunit-selective antagonism of recombinant N-methyl-D-aspartate receptors J. Biol. Chem. 276:26860-26867
Jimenez,E.C., Donevan,S., Walker,C., Zhou,L.M., Nielsen,J., Cruz,L.J., Armstrong,H., White,H.S. and Olivera,B.M. (2002) Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency Epilepsy Res. 51:73-80
White,H.S., McCabe,R.T., Armstrong,H., Donevan,S.D., Cruz,L.J., Abogadie,F.C., Torres,J., Rivier,J.E., Paarmann,I., Hollmann,M. and Olivera,B.M. (2000) In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus J. Pharmacol. Exp. Ther. 292:425-432
Blandl,T., Warder,S.E., Prorok,M. and Castellino,F.J. (2000) Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R FEBS Lett. 470:139-146

Internal links
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot P58806
Ncbi P58806

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