Pn10.1 [ribbon] (P10739) Protein Card

General Information
Name Pn10.1 [ribbon] (named by ConoServer)
Alternative name(s) PnID B
Organism Conus pennaceus
Organism region Indo-Pacific
Organism diet molluscivorous
Protein Type Wild type
Notes
  • Disulfide bond connectivity (C3-C12, C4-C9) (Espiritu et al., 2023).
  • Pn10.1 [ribbon] (PnID B) selectively inhibited uptake at the norepinephrine transporter (NET) with IC50 = 10 ± 1.75 µM.(Espiritu et al., 2023)
  • Pn10.1 [ribbon] (PnID B) did not show inhibition at the serotonin transporter (SERT), and the dopamine transporter (DAT) (Espiritu et al., 2023).
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    Classification
    Conopeptide class conotoxin
    Gene superfamily T superfamily
    Cysteine framework X
    Pharmacological family chi conotoxin

    Sequence
    STCCGYRMCVPC(nh2)
    Modified residues
    positionsymbolname
    13nh2C-term amidation
    Sequence evidence protein level
    Average Mass 1317.58
    Monoisotopic Mass 1316.46
    Isoelectric Point 10.94
    Extinction Coefficient [280nm] 1490.00

    References
    Conticello,S.G., Gilad,Y., Avidan,N., Ben-Asher,E., Levy,Z. and Fainzilber,M. (2001) Mechanisms for evolving hypervariability: the case of conopeptides Mol. Biol. Evol. 18:120-131
    Espiritu,M.J., Taylor,J.K., Sugai,C.K., Thapa,P., Loening,N.M., Gusman,E., Baoanan,Z.G., Baumann,M.H., and Bingham,J.P. (2023) Characterization of the Native Disulfide Isomers of the Novel χ-Conotoxin PnID: Implications for Further Increasing Conotoxin Diversity. Mar Drugs 21:61

    Internal links
    Nucleic acids
    Structure Structure of the ribbon isoform of the novel conotoxin PnID derived from Conus pennaceus

    External links

    Tools