Ile-SII(3-14)-NH2 (P10491) Protein Card

General Information
Name Ile-SII(3-14)-NH2
Organism synthetic construct
Protein Type Synthetic
Parent SII

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
ICCNPACGPNYGC(nh2)
Modified residues
positionsymbolname
14nh2C-term amidation
Average Mass 1309.50
Monoisotopic Mass 1308.45
Isoelectric Point 8.09
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50Ref
α1β1δεR. norvegicus(mouse epsilon subunit)221 nM+/-32Wilhelm,P. et al. (2022)
α1β1γδR. norvegicus778 nM+/-165Wilhelm,P. et al. (2022)

References
Wilhelm,P., Luna-Ramirez,K., Chin,Y.K., Dekan,Z., Abraham,N., Tae,H.S., Chow,C.Y., Eagles,D.A., King,G.F., Lewis,R.J., Adams,D.J., and Alewood,P.F. (2022) Cysteine-Rich α-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. ACS Chemical Neurosci 13:1245-1250

Internal links
Nucleic acids
Structure

External links

Tools