ArchIIIA (P10480) Protein Card

General Information
Name ArchIIIA
Organism Conus archon (magistrate cone)
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily M superfamily
Cysteine framework III
Pharmacological family alpha conotoxin

Sequence
CCSALCSRYHCLPCC
Sequence evidence protein level
Average Mass 1655.96
Monoisotopic Mass 1654.56
Isoelectric Point 11.65
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α7H. sapiens45.7 uM[39.1-53.5]100 uM AChHernández-Sámano,A.C. et al. (2022)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α3β2H. sapiens4.75+/-6.0445.7 uM100 uM AChHernández-Sámano,A.C. et al. (2022)
α7β2H. sapiens20.98+/-2.2745. uM100 uM AChHernández-Sámano,A.C. et al. (2022)

References
Hernández-Sámano,A.C., Falcón,A., Zamudio,F., Michel-Morfín,J.E., Landa-Jaime,V., López-Vera,E., Jeziorski,M.C., Aguilar,M.B. (2022) A short framework-III (mini-M-2) conotoxin from the venom of a vermivorous species, Conus archon, inhibits human neuronal nicotinic acetylcholine receptors. Peptides 153:170785

Internal links
Nucleic acids
Structure

External links

Tools