GeXIVA[insC_GAG, ribbon] cyclic (P10452) Protein Card

General Information
Name GeXIVA[insC_GAG, ribbon] cyclic (named by ConoServer)
Alternative name(s) Ribbon cGeXIVA_GAG,cGeXIVA_GAG[1,4]
Organism synthetic construct
Protein Type Synthetic
Parent GeXIVA[ribbon]
Notes Yousuf et al. (2021) discovered that cGeXIVA_GAG[1,4] activates GABAB receptor-mediated inhibition of Cav2.2 channel. ~60% inhibition of baclofen-sensitive Ba2+ current at 1 µM cGeXIVA_GAG[1,4] was obtained.

Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Average Mass 3620.08
Monoisotopic Mass 3617.69
Isoelectric Point 13.04
Extinction Coefficient [280nm] 4470.00


Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α9α10H. sapiens72+/-1100 nMAch (6 uM)Wu X et al. (2017)

Yousuf,A., Wu,X., Bony,A.R., Sadeghi,M., Huang,Y.H., Craik,D.J., Adams,D.J. (2021) αO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV 2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation J Neurochem
Wu X, Huang YH, Kaas Q, Harvey PJ, Wang CK, Tae HS, Adams DJ, Craik DJ. (2017) Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer J Biol Chem 292:17101-17112

Internal links
Nucleic acids

External links