GeXIVA[insC_GG, ribbon] cyclic (P10451) Protein Card

General Information
Name GeXIVA[insC_GG, ribbon] cyclic (named by ConoServer)
Alternative name(s) Ribbon cGeXIVA_GG,cGeXIVA_GG[1,4]
Organism synthetic construct
Protein Type Synthetic
Parent GeXIVA[ribbon]
Notes Yousuf et al. (2021) discovered that cGeXIVA_GG[1,4] did not activate GABAB receptor-mediated activation of Cav2.2 channel.

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
TCRSSGRYCRSPYDRRRRYCRRITDACVGG
Average Mass 3549.01
Monoisotopic Mass 3546.65
Isoelectric Point 13.04
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α9α10H. sapiens37.6 nM+/-4.9Ach (6 uM)Wu X et al. (2017)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α9α10H. sapiens66+/-3100 nMAch (6 uM)Wu X et al. (2017)

References
Yousuf,A., Wu,X., Bony,A.R., Sadeghi,M., Huang,Y.H., Craik,D.J., Adams,D.J. (2021) αO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV 2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation J Neurochem
Wu X, Huang YH, Kaas Q, Harvey PJ, Wang CK, Tae HS, Adams DJ, Craik DJ. (2017) Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer J Biol Chem 292:17101-17112

Internal links
Nucleic acids
Structure

External links

Tools